Tottenham will host Newcastle in the only all-Premier League match of the quarter-finals while Southampton travel to Sheffield United to complete the last-eight ties
Chelsea will travel to Derby County while Liverpool will take on Bournemouth following the draw for the quarter-finals of the League Cup.
Elsewhere, Manchester City’s conquerors, Newcastle, will face Tottenham in an all-Premier League tie while League One Sheffield United host Southampton.
Jose Mourinho’s side faced the Rams in the third round of last season’s FA Cup – winning 2-0 – and will again take on Steve McClaren’s side in their pursuit of the first available silverware of the season.
Liverpool, meanwhile, have scraped past Middlesbrough and Swansea City in the earlier rounds and face their first away trip of the competition when they take on Eddie Howe’s Championship high-flyers.
Tottenham saw off Brighton and Hove Albion on Wednesday to book their place in the last eight and will host Alan Pardew’s side in a repeat of their recent Premier League defeat at White Hart Lane.
And Nigel Clough’s Sheffield United, who are the lowest-ranked team left in the competition, will look to reach the last four of a domestic cup competition for the second consecutive season when they face Ronald Koeman’s buoyant Saints.
The ties will be played in the week beginning December 15.
Draw in full:
Derby County v Chelsea
Tottenham v Newcastle
Bournemouth v Liverpool
Sheffield United v Southampton